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Equest

Contra-indications, warnings, etc

Horses must not be slaughtered for human consumption within 32 days of treatment.

Do not administer to young foals less than 4 months of age.

EQUEST Oral Gel is formulated specifically for use in horses only. Dogs or cats may be adversely affected by the concentration of moxidectin in this product if they are allowed to ingest spilled gel or have access to used syringes.

Do not administer in case of known hypersensitivity to the active ingredient or to any other milbemycins and to any other ingredients of the veterinary medicinal product.

Do not use the same syringe to treat more than one animal unless horses are running together or in direct contact with each other on the same premises.

Do not smoke, drink or eat while handling the product.

The use of protective gloves is recommended.

Wash hands or any exposed area after use.

Avoid direct contact with skin and eyes.

In the event of eye contact, flush the eye with copious amounts of clean water and seek medical advice.

For animal treatment only.

Keep out of reach of children.

Read entire package insert before use.

Environmental safety

EQUEST Oral Gel is toxic to fish and aquatic organisms. Do not contaminate ponds, waterways or ditches with product or used syringes. Dispose of any unused product and empty syringes in accordance with guidance from your local waste regulation authority

Presentation
A clear gel containing 18.92 mg/g moxidectin and 37.84 mg/g benzyl alcohol and 0.24 mg/g disodium edetate as preservatives.
Uses         
Moxidectin is a second generation macrocyclic lactone of the milbemycin family.
For the treatment and control of adult and larval stages of important internal parasites including encysted inhibited EL3 and developing intramucosal L4 larval stages of small redworms, arterial stages of large redworms and bots in horses and ponies with a single dose.
EQUEST Oral Gel, at the recommended dosage level of 400 mcg moxidectin per kg bodyweight, provides effective control of moxidectin sensitive strains of the following parasites of horses and ponies:
Large strongyles:
Strongylus vulgaris (adults and arterial stages)
Strongylus edentatus (adults and visceral stages)
Triodontophorus brevicauda (adults)
Triodontophorus serratus (adults)
Triodontophorus tenuicollis (adults)
Small strongyles (adults and intraluminal larval stages):
Cyathostomum spp.
Cylicocyclus spp.
Cylicostephanus spp.
Cylicodontophorus spp.
Gyalocephalus spp.
EQUEST Oral Gel is effective against (developing) intramucosal L4 stages of small strongyles. At eight weeks after treatment early (hypobiotic) EL3 stages of small strongyles are eliminated.
EQUEST Oral Gel is effective against benzimidazole resistant strains of cyathostomes.
Ascarids:
Parascaris equorum (adult and larval stages)
Other species:
Oxyuris equi (adult and larval stages)
Habronema muscae (adults)
Gasterophilus intestinalis (L2, L3)
Gasterophilus nasalis (L2, L3)
Strongyloides westeri (adults)
Trichostrongylus axei
EQUEST Oral Gel has a persistent effect in preventing infection by small strongyles for 2 weeks after dosing and suppresses the presence of small strongyle eggs in the dung for 90 days.

 

Dosage and administration
For oral administration. One 12.2g syringe contains sufficient gel to treat one 575 kg horse at the recommended dose rate (0.4 mg moxidectin per kg bodyweight). Each graduation on the calibrated syringe delivers sufficient gel to treat 25 kg bodyweight. Use of a scale or weigh tape is recommended to ensure accurate dosing. To avoid overdosing, care should be taken to accurately dose foals, especially low bodyweight foals or young ponies.

 

Dosing guideline
The persistent activity of EQUEST Oral Gel and its effectiveness against inhibited and developing larvae in the intestinal mucosa enables a reduction in the dosing frequency in strategic parasite control programmes. The recommended dosing interval for the control of small strongyles is 13 weeks. Consult your veterinary surgeon for the appropriate programme for your specific needs

 

Pharmaceutical precautions
After opening, use within 6 months.
Do not store above 25°C.
Keep the syringe in the carton.
After first use record the date to be disposed on the label space provided.
 
           
Further information
EQUEST Oral Gel is safe to use in foals over 4 months of age, mares, ponies and horses. Mares may be treated at any stage of pregnancy and lactation. Transient adverse reactions may occur at twice the recommended dose in foals and 3 times the recommended dose in adults. The signs are depression, inappetence, ataxia and drooping lower lip 8 to 24 hours following dosing. Symptoms of moxidectin overdose are the same as those observed in very rare occasions at the recommended dosage. In addition, hypothermia may occur. Symptomatic treatment is not generally necessary and recovery is generally complete within 24 to 72 hours. There is no specific antidote.
EQUEST Oral Gel is specially formulated to be easily expelled by the syringe plunger. Once in the horse`s mouth, EQUEST Gel liquefies. This facilitates dosing and reduces the risk of rejection.