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Equest Pramox
Contra-indications,
warnings, etc
Horses must not be
slaughtered for human consumption within 64 days of treatment.
Do not administer to
young foals less than 6.5 months of age.
Do not use in cases of
hypersensitivity to the active substance or to any of the excipients.
Do not use during
pregnancy and lactation in mares.
EQUEST PRAMOX Oral Gel
is formulated specifically for use in horses only. Dogs or cats may be
adversely affected by the concentration of moxidectin in this product if
they are allowed to ingest spilled gel or have access to used syringes.
Do not use the same
syringe to treat more than one animal unless horses are running together
or in direct contact with each other on the same premises.
This product may cause
eye irritation, skin irritation and skin sensitisation.
Avoid direct contact
with skin and eyes.
The use of protective
gloves is recommended.
Wash hands or any
exposed area after use.
Do not smoke, drink or
eat while handling the product.
In the event of eye
contact flush the eye with copious amounts of clean water and seek
medical advice.
In case of accidental
ingestion, seek medical help and show the doctor the package insert.
For animal treatment
only.
Keep out of the reach
and sight of children.
Read entire package
insert before use.
In order to limit the
impact of moxidectin on dung fauna, and due to insufficient data
regarding environmental risk of praziquantel, horses should not be
turned out onto pasture within 3 days of treatment.
EQUEST PRAMOX Oral Gel
is toxic to fish and aquatic organisms. Do not contaminate ponds,
waterways or ditches with product or used syringes. Dispose of any
unused product and empty syringes in accordance with guidance from your
local waste regulation authority.
A pale yellow to
orange/pink gel containing 19.5 mg/g moxidectin and 121.7 mg/g
praziquantel as active ingredients and 220.0 mg/g benzyl alcohol and
0.80 mg/g butyl hydroxytoluene as preservatives/antioxidants.
Moxidectin is a
second-generation macrocyclic lactone of the milbemycin family.
Praziquantel is a parasiticide widely used in many species for the
specific control of tapeworm. For the single dose treatment of mixed
cestode and nematode or arthropod infections in horses and ponies;
caused by moxidectin and praziquantel sensitive strains of:
Large redworm
(large strongyles):
-
Strongylus vulgaris (adults)
-
Strongylus edentatus (adults)
-
Triodontophorus brevicauda (adults)
-
Triodontophorus serratus (adults)
-
Triodontophorus tenuicollis (adults)
Small redworm
(small strongyles/cyathostomin) (adults and intraluminal larval
stages):
-
Parascaris equorum (adults)
-
Habronema muscae (adults)
-
Strongyloides westeri (adults)
-
Trichostrongylus axei (adults)
-
Gasterophilus intestinalis (L2, L3)
-
Gasterophilus nasalis (L2, L3)
-
Anoplocephala perfoliata
-
Anoplocephaloides mamillana
The egg
reappearance period of small redworm is 90 days.
The product is
effective against (developing) intramucosal L4 stages of small
redworm. At 8 weeks after treatment, early (hypobiotic/inhibited)
EL3 stages of small redworm are eliminated.
The product is
effective against benzimidazole resistant strains of cyathostomes.
Dosage and
administration
For oral
administration. One 11.8g syringe contains sufficient gel to
treat a 575kg horse at the recommended dose rate (0.4mg
moxidectin per kg bodyweight and 2.5mg praziquantel per kg
bodyweight). Each graduation on the calibrated syringe delivers
sufficient gel to treat 25kg bodyweight. Use of a scale or
weight tape is recommended to ensure accurate dosing. To avoid
overdosing, care should be taken to accurately dose foals,
especially low bodyweight foals or pony foals.
The
recommended dosing interval for the control of small redworm is
13 weeks. For optimum control of bots, the product should be
administered in the autumn, after the end of the fly season and
before spring as the larvae may start to pupate and therefore
are less sensitive to treatment.
Veterinary
advice should be given on appropriate dosing programmes and
stock management to achieve optimum parasite control.
Pharmaceutical precautions
Use within
6 months after opening.
Do not use
after the expiry date stated on the carton after "EXP".
Parasite resistance to a particular class of
anthelmintic may develop following frequent, repeated
use of an anthelmintic of that class.
The
veterinary surgeon should give advice regarding
appropriate dosing programmes and stock management to
achieve adequate parasite control for both tapeworm and
roundworm infestations.
In the
case of cestode treatment the dose of praziquantel in
the product has been selected at the top end of the
dosing range.
Flaccid lower lip, ataxia and swelling of the muzzle
could be observed on rare occasions in young animals.
These adverse effects are transient and disappear
spontaneously. In adults transient adverse reactions may
occur at 3 times the recommended dose. The symptoms are
depression, inappetence, ataxia, flaccid lower lip in
the 8 to 24 hours following treatment. Symptomatic
treatment is not generally necessary and recovery is
generally complete within 24 to 72 hours.
There
is no specific antidote.
In
case of very high worm burdens, destruction of the
parasites may cause a mild transient colic and loose
faeces in the treated horse.
EQUEST
PRAMOX Oral Gel is specially formulated to be easily
expelled by the syringe plunger. Once in the horse’s
mouth, EQUEST PRAMOX Oral Gel liquefies. This
facilitates dosing and reduces the risk of rejection.
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